Work

Cell Phenotyping: Multiparametric Biomechanical and Biochemical Phenotypic Profiling of Single Cancer Cells Using an Elasticity Microcytometer (Small 17/2016)

Year: 2016

Type: article

Abstract: An elasticity microcytometer capable of multiparametric biomechanical and biochemical phenotypic profiling of single cancer cells is developed to interpret cell deformation along antibody-coated confining microchannels as quantitative cell characteristics including cell size, cell deformability/stiffness, and expression levels of surface receptors simultaneously for the same single live cancer cells. This elasticity microcytometer, developed by R. H. W. Lam, J. Fu and co-workers on page 2300, holds a great promise for comprehensive molecular, cellular, and biomechanical phenotypic profiling of live cancer cells at the single cell level.

Source: Small

DOI: 10.1002/smll.201670084

Authors: Shuhuan Hu, Guangyu Liu, Weiqiang Chen, Xiang Li, Wei Lu, Raymond H. W. Lam, Jianping Fu

Institutions: City University of Hong Kong, University of Michigan, New York University, City University of Hong Kong, Shenzhen Research Institute

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2344462865

FWCI:

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