MSG-06: A Registry of 90 Cases of Phaeohyphomycosis
Year: 2015
Type: conference-abstract
Abstract: Background. Phaeohyphomycoses are infections caused by dematiaceous, or darkly pigmented fungi. These are rare and difficult to study in a systematic manner. Methods. The Mycoses Study Group, an international consortium of experts in mycology, sought to develop a detailed case registry (administered via Fungiscope; Cologne, Germany) of these uncommon fungal infections, as well as a collection of corresponding clinical isolates for further study. Results. Herein, we present the first 90 cases, collected from 13 sites in 3 countries (United States, Australia, Peru). 54% of patients were male. The most common genus was Scedosporium (prolificans) (18 cases), followed by Alternaria (10), Curvularia (9), Exophiala (8), Exserohilum (4), Ochroconis (4) and Cladophialophora(3). Most (80%) had some form of chronic immunosuppression, primarily organ and stem cell transplantation. A variety of clinical syndromes were observed: 32 skin and soft tissue, 23 pulmonary, 14 disseminated infections, 12 sinusitis, 11 central nervous system, 9 bone/joint, along with 5 cases of endophthalmitis, 3 mycetoma, 2 endocarditis and 1 peritonitis (some patients had more than one site involved). Antifungal therapy was administered in 86% of cases, including voriconazole (37), lipid amphotericin B formulations (14), posaconazole (8) and itraconazole (14). Surgery was performed in 29 cases. Overall mortality was high through end of follow-up (31%), though only 13 patients were known to have died due to fungal infection. Follow-up ranged from 1-39 months (average 3 months). Conclusion. We report the first such case registry of these mycoses in order to better understand and manage these rare infections. Disclosures. S. Revankar, Astellas: Investigator, Research grant. Merck: Investigator, Research grant. Gilead: Investigator, Research grant; J. Baddley, Pfizer: Consultant, Consulting fee. BMS: Grant Investigator, Research grant; S. Chen, Pfizer Australia: Grant Investigator and Investigator, Research support; M. Vehreschild, Pfizer: Speaker's Bureau, Speaker honorarium. Merck: Consultant and Speaker's Bureau, Consulting fee and Speaker honorarium. Gilead: Investigator and Speaker's Bureau, Research grant and Speaker honorarium. Astellas: Consultant, Investigator and Speaker's Bureau, Consulting fee, Research grant and Speaker honorarium. 3M: Investigator, Research grant. DaVolterra: Consultant and Investigator, Consulting fee and Research grant. Berlin Chemie: Consultant, Consulting fee; K. Wahlers, Merck: Investigator and Speaker's Bureau, Research grant and Speaker honorarium. Astellas: Speaker's Bureau, Speaker honorarium. Gilead: Consultant, Travel grants; P. Pappas, Merck: Investigator, Research grant. Astellas: Investigator, Research grant. Gilead: Investigator, Research grant
Source: Open Forum Infectious Diseases
Authors: Sanjay Revankar, John Baddley, Sharon Chen, Maria Vehreschild, Kerstin Wahlers, Peter Pappas, Study Investigators
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W2344677652