Year: 2016
Type: review
Abstract: Homologous recombination (HR) is a central process to ensure genomic stability in somatic cells and during meiosis. HR-associated DNA synthesis determines in large part the fidelity of the process. A number of recent studies have demonstrated that DNA synthesis during HR is conservative, less processive, and more mutagenic than replicative DNA synthesis. In this review, we describe mechanistic features of DNA synthesis during different types of HR-mediated DNA repair, including synthesis-dependent strand annealing, break-induced replication, and meiotic recombination. We highlight recent findings from diverse eukaryotic organisms, including humans, that suggest both replicative and translesion DNA polymerases are involved in HR-associated DNA synthesis. Our focus is to integrate the emerging literature about DNA polymerase involvement during HR with the unique aspects of these repair mechanisms, including mutagenesis and template switching.
Source: Annual Review of Genetics
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Mechanisms and consequences of inaccurate DNA double-strand break repair, G3090254282, G408160331, G4119534169, Training Program in Oncogenic Signals and Chromosome Biology, G5850682332, Mutations Arising During DNA Repair, G6462277749, SMALL MOLECULE INHIBITORS OF RECOMBINATIONAL DNA REPAIR, Regulation of Recombinational DNA Repair, G9000004211, G9000295906
OpenAlex ID: W2344857673