Year: 2016
Type: article
Study design: Case Report
Abstract: A middle-aged woman presented for evaluation of gingival swelling. She was previously diagnosed with hypoplasminogenemia and current plasminogen level was 29% (reference value: 78–130%). Intraoral examination revealed swelling of the right maxillary gingiva (Figure 1). Biopsy with routine histopathologic analysis revealed fibrinoid deposits and a mixed inflammatory infiltrate within the lamina propria, consistent with hypoplasminogenemia (Figure 2). Hypoplasminogenemia (type 1 plasminogen deficiency) is commonly associated with ligneous conjunctivitis and ligneous gingivitis.1–3 An oral mucosal biopsy can aid in the diagnosis of this rare condition as histopathologic evidence of fibrin deposition is highly suggestive of hypoplasminogenemia.2,3
Authors: Eric T. Stoopler, Faizan Alawi
Institution: University of Pennsylvania
Language: English
Subfield: Pharmacy
Field: Health Professions
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2345369697