Work

IGF 2 BP 2 promotes colorectal cancer cell proliferation and survival through interfering with RAF ‐1 degradation by miR‐195

Year: 2016

Type: article

Abstract: Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is a post-transcriptional regulatory factor implicated in mRNA localization, stability, and translational control. However, the role of IGF2BP2 regulation in colorectal cancer (CRC) and its underlying mechanism remain elusive. In this study, we found that IGF2BP2 expression is markedly increased in CRC tissues. Notably, IGF2BP2 overexpression strikingly enhanced the proliferation and survival of CRC cells in vitro, whereas its shRNA-mediated silencing resulted in the opposite. Molecular function analyses revealed that IGF2BP2 regulates RAF1 expression through blocking its degradation by miR-195. These results identify IGF2BP2 as a post-transcriptional regulatory mRNA-binding factor that contributes to CRC carcinogenesis.

Source: FEBS Letters

DOI: 10.1002/1873-3468.12205

Authors: Song Ye, Wei Song, Xiaogang Xu, Xinyi Zhao, Liu Yang

Institutions: First Affiliated Hospital Zhejiang University, Zhejiang University, Zhejiang Provincial People's Hospital

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, Chinese Society of Clinical Oncology, National High-tech Research and Development Program