Work

Reductive Umpolung of Carbonyl Derivatives with Visible‐Light Photoredox Catalysis: Direct Access to Vicinal Diamines and Amino Alcohols via α‐Amino Radicals and Ketyl Radicals

Year: 2016

Type: article

Abstract: Visible-light-mediated photoredox-catalyzed aldimine-aniline and aldehyde-aniline couplings have been realized. The reductive single electron transfer (SET) umpolung of various carbonyl derivatives enabled the generation of intermediary ketyl and α-amino radical anions, which were utilized for the synthesis of unsymmetrically substituted 1,2-diamines and amino alcohols.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201511235

Authors: Eleonora Fava, Anthony Millet, Masaki Nakajima, Sebastian Loescher, Magnus Rueping

Institutions: RWTH Aachen University, King Abdullah University of Science and Technology

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,510

Funders: European Commission, European Research Council