Year: 2016
Type: article
Abstract: Multiple myeloma (MM) incidence and mortality are higher among African Americans (AAs) than among other population groups. The prevalence of obesity is also elevated among AAs, but few studies have examined risk of this cancer in relation to body size among AAs. We combined data from seven prospective cohorts tracking mortality among 239 597 AA adults and used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for death because of MM according to body mass index (BMI) at cohort entry, adjusted for age (as time-scale) and sex. Relative to those with normal BMIs (18.5-25 kg/m(2)), mortality increased monotonically as BMI increased, with hazard ratios reaching 1.43 (95% CI = 1.03 to 1.97) for BMIs of 35 kg/m(2) or greater. The findings suggest that obesity is a risk factor for MM and a contributor to the elevated rates and rising incidence trends of MM among AAs in the United States.
DOI: 10.1093/jnci/djw120
Authors: Jennifer S. Sonderman, Traci N. Bethea, Cari M. Kitahara, Alpa V. Patel, Chinonye Harvey, Synnøve F. Knutsen, Yikyung Park, Song-Yi Park, Gary E. Fraser, Lauren R. Teras, Mark P. Purdue, Rachael Z. Stolzenberg-Solomon, Elizabeth M. Gillanders, Julie R. Palmer, Laurence N. Kolonel, William J. Blot
Institutions: Boston University, University of Hawaiʻi at Mānoa, American Cancer Society, National Institutes of Health, University of Hawaii System, Washington University in St. Louis, Loma Linda University, National Cancer Institute, International Epidemiology Institute, University of Hawaii Cancer Center, Division of Cancer Epidemiology and Genetics, Vanderbilt University Medical Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1161922357, Southern Community Cohort Study, G153510172, Plant-based diets and risk of cancer, G2548880556, A Follow-up Study for Causes of Illness in Black Women, G4407166175, G4858979163, G5190555239, G5654214539, CANCER EPIDEMIOLOGY IN ADVENTISTS--A LOW RISK GROUP, A Follow-up Study for Causes of Cancer in Black Women, G9000021152, G9000051068, G9000076846, G9000216949, G9000233422
OpenAlex ID: W2345962463