Work

Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS

Year: 2016

Type: review

Abstract: HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS, transforming this deadly ailment into a more manageable chronic infection. Over the years, intensive research has led to a variety of approved protease inhibitors for the treatment of HIV/AIDS. In this review, we outline current drug design and medicinal chemistry efforts toward the development of next-generation protease inhibitors beyond the currently approved drugs.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5b01697

Authors: Arun K. Ghosh, Heather L. Osswald, Gary Prato

Institution: Purdue University West Lafayette

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Purdue University, National Institute of General Medical Sciences