Work

Incorporation of gallium-68 into the crystal structure of Prussian blue to form K 68 Ga x Fe 1−x [Fe(CN) 6 ] nanoparticles: toward a novel bimodal PET/MRI imaging agent

Year: 2016

Type: article

Abstract: Similarity between the Ga(+) ion and the Fe(3+) ion allows for partial replacement of Fe(3+) ions with Ga(3+) ions in the Fe(iii) crystallographic positions in Prussian blue (PB) to form various solid solutions KGaxFe1-x[Fe(CN)6] (0 < x < 1). Such solid solutions possess very high thermodynamic stability as expected from the parent PB structure. Consequently, a simple one-step (68)Ga-labeling method was developed for preparing a single-phase nanoparticulate bimodal PET/MRI imaging agent based on the PB structural platform. Unlike the typical (68)Ga-labelling reaction based on metal complexation, this novel chelator-free (68)Ga-labeling reaction was shown to be kinetically fast under the acidic conditions. The Ga(3+) ion does not hydrolyze, and affords the (68)Ga-labelled PB nanoparticles, which are easy to purify and have extremely high stability against radionuclidic leaching in aqueous solution.

Source: Dalton Transactions

DOI: 10.1039/c6dt00962j

Authors: Murthi S. Kandanapitiye, Matthew D. Gott, Andrew Sharits, Silvia S. Jurisson, Patrick M. Woodward, Songping D. Huang

Institutions: Kent State University, University of Missouri, Columbia University, The Ohio State University

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid