Year: 2014
Type: article
Abstract: In this issue of the JCI, Chaurasia and colleagues report an impressive ex vivo expansion of HSCs from human cord blood (CB) using cytokines and altering epigenetic modifications. The application of this protocol provides information that has potential for clinical consideration. The enhanced expansion of CB HSCs is a substantial advance over recent work from the Chaurasia and Hoffman group, in which ex vivo production of human erythroid progenitor cells from CB was promoted by chromatin modification. Moreover, this study takes advantage of information from the rapidly emerging, but not yet fully elucidated, field of epigenetics.
DOI: 10.1172/jci75803
Author: Hal E. Broxmeyer
Institution: Duke Medical Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Mechanisms of Synergistic Regulation of Stem/Progenitors, Regulating hematopoietic stem cells and hematopoiesis for clinical efficacy, Cytokine Enhancement of Myeloid Progenitor Cell Survival, G5700285684, Enhancing Engraftment of Cord Blood by CD26 Inhibition, Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy
OpenAlex ID: W2004684788