Effectiveness of switching from oral ziprasidone to risperidone in a patient with comorbid autistic disorder, profound intellectual disability, Gilbert syndrome, and exacerbation of psychosis.
Year: 2016
Type: article
Study design: Case Report
Abstract: Autism and intellectual disability may hinder any other coexisting psychiatric diagnosis. Diagnoses are often based on behavioral observations, directly ob- tained or reported by family members or operators in frequent contact with the patient, and non-verbal communications, as well as on the psychological and physical symptoms manifested by the patient. We describe the case of a 28-year-old Italian man, hospitalized in one of our long-term care wards for comorbid profound intellectual disability (IQ<25), autistic and psychotic disorders, and Gilbert syndrome, who manifested a severe exacerbation of psychosis, for which ziprasidone was prescribed. This condition para- doxically further deteriorated after the introduction of this drug. A subsequent switch to risperidone greatly and rapidly improved both psychosis-related and symp- toms emerging after the introduction of ziprasidone.
Source: PubMed
Authors: Antonio Del Casale, Georgios D Kotzalidis, Michele Sacco, Chiara Rapinesi, Riccardo De Giorgi, Marco Giardini, Michele D'Andreagiovanni, Nicola Carlino, Roberto Brugnoli, Paolo Girardi
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2346938818