Year: 2016
Type: review
Abstract: The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates. We are discussing primary, secondary and tertiary structural aspects including approaches to organize multivalency.
Source: Chemical Society Reviews
DOI: 10.1039/c6cs00165c
Authors: Christian Müller, Guillaume Despras, Thisbe K. Lindhorst
Institution: Christian-Albrechts-Universität zu Kiel
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Funder: Deutsche Forschungsgemeinschaft
Award: G319404503
OpenAlex ID: W2347068472