Progression of miR-451 in erythroid differentiation and tumor
Year: 2012
Type: article
Abstract: miRNAs,as an endogenous small molecule RNA,play key roles in a wide variety of normal and pathological cellular processes.miR-451 plays important roles in promoting erythroid differentiation and maturation,and significantly decreases expression in glioma,gastrointestinal cancer,lung cancer and other tumor tissues.Increased miR-451 can significantly inhibit tumor cell proliferation,invasion and metastasis as well as increase tumor cell apoptosis and improve radiotherapy and chemotherapy sensitivity and other biological effects.In this review,we summarized the recent advances in the roles of miR-451 in hematopoietic cell differentiation and tumor development.
Source: Chinese Clinical Oncology
Author: Zhao‐Xi Wang
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2347522638