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Programmable biomaterials for dynamic and responsive drug delivery

Year: 2016

Type: article

Abstract: Biomaterials are continually being designed that enable new methods for interacting dynamically with cell and tissues, in turn unlocking new capabilities in areas ranging from drug delivery to regenerative medicine. In this review, we explore some of the recent advances being made in regards to programming biomaterials for improved drug delivery, with a focus on cancer and infection. We begin by explaining several of the underlying concepts that are being used to design this new wave of drug delivery vehicles, followed by examining recent materials systems that are able to coordinate the temporal delivery of multiple therapeutics, dynamically respond to changing tissue environments, and reprogram their bioactivity over time.

Source: Experimental Biology and Medicine

DOI: 10.1177/1535370216649445

Authors: Anna Stejskalová, Mehrdad T Kiani, Benjamin D Almquist

Institution: Imperial College London

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Whitaker International Program, Imperial College London