Work

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

Year: 2012

Type: article

Abstract: We designed and synthesized a BODIPY-based probe (BAP-1) for the imaging of β-amyloid plaques in the brain. In binding experiments in vitro, BAP-1 showed excellent affinity for synthetic Aβ aggregates. β-Amyloid plaques in Tg2576 mouse brain were clearly visualized with BAP-1. In addition, the labeling of β-amyloid plaques was demonstrated in vivo in Tg2576 mice. These results suggest BAP-1 to be a useful fluorescent probe for the optical imaging of cerebral β-amyloid plaques in patients with Alzheimer's disease.

Source: ACS Chemical Neuroscience

DOI: 10.1021/cn3000058

Authors: Masahiro Ono, Hiroyuki Watanabe, Hiroyuki Kimura, Hideo Saji

Institution: Kyoto University

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Japan Society for the Promotion of Science