Year: 2011
Type: dissertation
Abstract: Introduction: Cystic fibrosis (CF) is the most lethal genetic disease observed in the caucasian population.Despite having a multiorganic involvement, the predominant manifestations and the ones which cause higher levels of mortality and morbidity are the pulmonary ones.The pulmonar deterioration is persistent and irreversible.When reached the point when medical treatment doesn't provide effective, lung transplantation appears as the only therapy available.Objectives: Identify the importance of lung transplantation in patients with CF and its impact on the quality of live and the increase of the prolong survival.Define accurate indications for transplantation as well as timings in which it must be done.Evaluate possible complications of the transplant and its effectiveness.Development: In spite of the fact that the indications for transplants are not consensual among all centers, the indication which is most used to indicate a patient to transplant surgery is the volume of air exhaled during the first second (FEV 1 ).However, this parameter alone wasn't a good enough indicator to the response of the transplant.It should not be used alone, but taking into account other factors.In 2005, was created an index called Lung allocation score system, which was held in order to create a better distribution of the donated lungs.The implementation of this index allowed a decrease in the waiting time for transplant and a decrease in the mortality rate among patients awaiting transplant.As already happened with the indications, the contraindications didn't come to an agreement among all the centers.The major divergences appear in relation to the infections contraindications.The one which appears to have a greater negative impact in the survival is the infection with Burkholderia cenocepacia.Complications associated with transplantation are a major cause of mortality, including rejection and infection.Conclusion: Lung transplantation is the only definitive treatment for patients with CF, yet there are still doubts associated with the indications and prognosis.
DOI: 10.34626/bp85-va66
Language: Portuguese
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W235902231