Work

Mitochondrial One-Carbon Metabolism Maintains Redox Balance during Hypoxia

Year: 2014

Type: article

Abstract: Summary: Mitochondria generate high levels of reactive oxygen species (ROS) to activate protumorigenic signaling pathways. In parallel, the mitochondria must also increase their antioxidant capacity to lower ROS levels and prevent cancer cell death. In this issue of Cancer Discovery, Ye and colleagues demonstrate that serine catabolism through one-carbon metabolism within the mitochondrial matrix is necessary to maintain this redox balance. Cancer Discov; 4(12); 1371–3. ©2014 AACR. See related article by Ye et al., p. 1406

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-14-1228

Authors: Inmaculada Martínez-Reyes, Navdeep S. Chandel

Institution: Northwestern University

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute