Protective Effect of C-phycocyanin against Inflammation and Interstitial Fibrosis in an Obstructive Nephropathy Model
Year: 2010
Type: article
Abstract: 허혈성신손상,이식신거부반응,사구체신염및간질성신염등모든신장질환에서염증반응은중요한역할을차지하며,진행시기및정도에따라다양한염증세포와싸이토카인들이관여하는복잡한과정을거쳐치유또는손상으로이어진다.이과정에서섬유화(fibrosis)가발생하며,이는사구체경화(glomerularsclerosis)와간질섬유화(interstitialfibrosis)로대변된다.신장의염증반응및섬유화에대해수많은연구가진행되어다양한기전이알려졌고,이를바탕으로신손상을최소화하려는여러방법들이제시되어왔다.다양한신질환에대한대표적인동물모델로사구체손상을주로보이는5/6신절제모델과,이와대조적으로세뇨관이나간질손상이주를이루는요로폐쇄모델,허혈/재관류모델이나신독성약물에의한모델을들수있다
Author: Sung Joon Shin
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2373544351