Neuroprotective Effect of Exogenous Growth Hormone in Brain Injury-Rat Model
Year: 2006
Type: article
Abstract: Objective: To evaluate the neuroprotective effect of growth hormone (GH) following lateral fluid percussion brain injury. Method: Sprague-Dawley rats weighing 200250 g were subjected to moderate lateral fluid percussion brain injury and evaluated at 1, 7, 14 and 28 days post-injury. Rats were divided into control and GH pretreatment groups. GH () or normal saline () was administered by intracerebro-ventricular injection 30 min before brain injury. We measured histopathological changes with TUNEL and toluidine blue Nissl stain and conducted motor function tests and an 8-arm radial maze test to identify neurobehavioral deficits and cognitive deficits, respectively, at one day to 4 weeks post-injury. Results: In the pretreated GH group, a significant reduction in TUNEL-positive cells was found compared with the control group at 1 day and 1 week post-injury (p
Authors: Hee-Seung Yang, Min-Ho Chun, Don‐Kyu Kim, Sang‐Tae Kim, Hee-Jin Jo
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $153
OpenAlex ID: W2374406858