A double-blind,randomized,controlled trial of minocycline combined with risperidone in the treatment of negative symptoms in early-phase schizophrenia
Year: 2014
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objective Exploring the efficacy of minocycline combining with risperidone in the treatment of negative symptom of early-phase schizophrenia.Methods Ninety-two patients with early stage schizophrenia treated with risperidone were randomly assigned to receive minocycline or placebo.Two treatment group both take 16-weeks.The clinical effect and adverse reactions were assessed with the Scale for the Assessment of Negative Symptoms( SANS),the Positive and Negative Syndrome Scale( PANSS),Barnes Akathisia Scale( Barnes) and Simpson Extrapyramidal Rating Scale( SAS) before the treatment and after.Results Subjects receiving minocycline had greater improvements on SANS total scores,PANSS negative subscale scores and PANSS total score( P 0.01)when compared with those receiving placebo.Conclusion The addition of minocycline to atypical antipsychoticdrugs in early schizophrenia had significant efficacy on negative symptoms and had no serious side effect in patients with schizophrenia.
Source: Sichuan Mental Health
Author: Liu Fan
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2376820212