Efficiency of Body-γ-Knife for Patients with Primary Hepatocellular Carcinoma
Year: 2008
Type: article
Abstract: Objective To investigate the short and longterm therapeutic effectiveness and complication of body-γ-knife in patients with small hepatocellular carcinoma(SHCC).Methods Thirty-seven patients with SHCC were treated by bodyγ-knife therapy.The isodose curve(50%~60%) was covered about planning target volume(PTV),The isodose curve(60%~70%) was covered about gross tumor volumes(GTV).The biological effective dose is 80 Gy at least to the GTV.Twenty-seven patients was treated in combination with TACE 1 or 2 times.Results Tumor disappeared in 9 patients,tumor size decreased in 22 patients,remained unchanged in 4 patients,and enlarged in 2 patients.The local control rates were 83.78%(31/37).The overall survival rate of 1、2、3、4、5-year was 78.38%(29/37),62.16%(23/37),43.24%(16/37),32.43%(11/37),33.3%(5/15).The median follow-up duration was 27 months.The overall survival rate of 4 year with solitary lesion was 55.56%(11/20).The therapeutic effectiveness is comparable to radical operation with acceptable complication.Conclusion Body-γ-knife radiotherapy is a feasible approach of radical cure for patients refuse operation or are not suitable for operation. However,the suitable total dose and fractional dose need further discussion.
Source: Zhongliu fangzhi yanjiu
Author: Wei Liu
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $72
OpenAlex ID: W2380620953