Comparison of gene expression between naturally occurring and diet-induced T2DM in cynomolgus monkeys
Year: 2013
Type: article
Abstract: To explore pathological alteration of T2DM in cynomolgus monkeys, gene expression profiles of peripheral blood leukocytes from spontaneous and diet-induced T2DM models was analyzed using quantitative real-time PCR. Among 36 T2DM associated genes tested, 19 genes (including G6PC, CCR2B, CTLA4) displayed a similar expression pattern in both spontaneous and diet-induced T2DM models and were significantly up-regulated or down-regulated compared to controls. Interestingly, expression abundance of all up-regulated genes in the diet-induced T2DM was stronger, although not significantly, than spontaneous models, indicating diet-induced T2DM in monkeys should be a reliable research model for changes in gene expression. The characteristic gene expression pattern obtained here may be useful for the clinical diagnosis of T2DM.
Source: Zoological Research
Authors: Fang JI, Li-Sha JIN, Xiao-Ming ZENG, Xiu-Juan ZHANG, Yan-Chun ZHANG, Yun-Xiao SUN, Li-Hua GAO, Hong HE, Jun-Hua RAO, Xiao-Ming LIU, Bai-Lu PENG
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2380936709