Progress of tumor-associated macrophages in breast cancer
Year: 2014
Type: article
Abstract: The development of breast cancer depends on the essential contributions from tumor microenvironment.Tumor-associated macrophages(TAMs) are a kind of the most important inflammatory cells in the tumor microenvironment.Most of them can facilitate angiogenesis,invasion and metastasis in breast cancer.TAMs may dull the effect of chemotherapy and radiotherapy.The panmacrophage marker CD68 is now generally utilized to identify TAMs in diagnostic biopsy samples,and some other TAMs-related biomarkers are also utilized in prognosis prediction,including CD163,vascular endothelial growth factor(VEGF),hypoxia-inducible factors(HIFs),proliferating cellular nuclear antigen(PCNA) and etc.Clinical evidences indicate the association between high TAMs infiltration and poor prognosis of breast cancer.In this review,we summarized the recent progress in understanding the relationship between TAMs and breast cancer.TAMs may be a potential prognostic biomarker and therapeutic target in breast cancer.Anti-TAMs therapy is a new way to improve the prognosis of breast cancer.
Source: Chinese Clinical Oncology
Author: Xuan Qiji
Institution: Harbin Medical University
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2381343457