Work

Structural Studies of G Protein-Coupled Receptors

Year: 2015

Type: review

Abstract: G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and structural insights of different aspects of GPCR biological functions.

Source: Molecules and Cells

DOI: 10.14348/molcells.2015.0263

Authors: Dandan Zhang, Qiang Zhao, Beili Wu

Institutions: Chinese Academy of Sciences, Shanghai Institute of Materia Medica

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500

Funder: National Natural Science Foundation of China