A case of fulminant hepatic failure due to cyproterone acetate in a patient with cryptogenic liver cirrhosis
Year: 2009
Type: article
Study design: Case Report
Abstract: Cyproterone acetate is an antiandrogenic drug that has been used in prostatic cancer. The drug is thought to be well-tolerated but has hepatotoxic effects. An 89 year-old man treated with cyproterone acetate 300 mg/d for prostatic cancer presented with a hepatotoxic reaction. Toxic hepatitis was diagnosed and cyproterone acetate was stopped immediately. The patient was treated with supportive management and a corticosteroid, but he died 28 days after administration due to liver failure. A liver biopsy performed after his death revealed the presence of acute hepatitis with cirrhosis. Underlying cirrhosis was not suspected before his death. Ultimately, the case was diagnosed as fulminant hepatic failure due to cyproterone acetate with underlying cryptogenic liver cirrhosis. This case and current literature highlight the hepatotoxic potential of cyproterone acetate and illustrate the importance of clinical surveillance, especially in patients with unrecognized liver disease.
Authors: Byoung‐Ho Kim, Dong Joon Kim, Kyoung-Min Sohn, Hana Yang, Myung-Jin Choi, Chanwoo Lee, Kyung‐Chan Choi
Institution: Hallym University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $500
OpenAlex ID: W2388692234