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Inflammasome, IL-1 and inflammation in ozone-induced lung injury.

Year: 2016

Type: article

Abstract: Exposure to ambient ozone causes airway hyperreactivity and lung inflammation, which represent an important health concern in humans. Recent clinical and experimental studies contributed to the understanding of the mechanisms of epithelial injury, inflammation and airway hyperreactivity, which is reviewed here. The present data suggest that ozone induced oxidative stress causes inflammasome activation with the release of IL-1, other cytokines and proteases driving lung inflammation leading to the destruction of alveolar epithelia with emphysema and respiratory failure. Insights in the pathogenic pathway may allow to identify novel biomarkers of ozone-induced lung disease and therapeutic targets.

Source: PubMed Central

Authors: Chloé Michaudel, Aurélie Couturier-Maillard, Pauline Chenuet, Isabelle Maillet, Catherine Mura, Isabelle Couillin, Aurélie Gombault, Valérie F Quesniaux, François Huaux, Bernhard Ryffel

Institutions: Centre National de la Recherche Scientifique, Immunologie et Neurogénétique Expérimentales et Moléculaires, UCLouvain, Institute of Infectious Disease and Molecular Medicine

Language: English

Topic: Air Quality and Health Impacts

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2391696268

FWCI: 4.051

Cites: 59

Cited by: 55

Related to: 10