Year: 2017
Type: article
Abstract: Summary Despite the huge international endeavor to understand the genomic basis of malaria biology, there remains a lack of information about two human-infective species: Plasmodium malariae and P. ovale . The former is prevalent across all malaria endemic regions and able to recrudesce decades after the initial infection. The latter is a dormant stage hypnozoite-forming species, similar to P. vivax . Here we present the newly assembled reference genomes of both species, thereby completing the set of all human-infective Plasmodium species. We show that the P. malariae genome is markedly different to other Plasmodium genomes and relate this to its unique biology. Using additional draft genome assemblies, we confirm that P. ovale consists of two cryptic species that may have diverged millions of years ago. These genome sequences provide a useful resource to study the genetic basis of human-infectivity in Plasmodium species.
Source: Nature
DOI: 10.1038/nature21038
Authors: Gavin G. Rutledge, Ulrike Böhme, Mandy Sanders, Adam J. Reid, James A. Cotton, Oumou Maiga-Ascofare, Abdoulaye A. Djimdé, Tobias O. Apinjoh, Lucas Amenga-Etego, Magnus Manske, John W. Barnwell, François Renaud, Benjamin Ollomo, Franck Prugnolle, Nicholas M. Anstey, Sarah Auburn, Ric N. Price, James S. McCarthy, Dominic P. Kwiatkowski, Chris I. Newbold, Matthew Berriman, Thomas D. Otto
Institutions: Wellcome Sanger Institute, Université des Sciences, des Techniques et des Technologies de Bamako, German Center for Infection Research, Malaria Research and Training Center, University of Buea, Navrongo Health Research Centre, Centers for Disease Control and Prevention, Centre National de la Recherche Scientifique, Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle, Institut de Recherche pour le Développement, Centre International de Recherches Médicales de Franceville, Charles Darwin University, Menzies School of Health Research, University of Oxford, The University of Queensland, QIMR Berghofer Medical Research Institute, Centre for Human Genetics, John Radcliffe Hospital, MRC Weatherall Institute of Molecular Medicine
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $12,690
Awards: G1201428007, G1893022765, G1924830673, Multi-gene families in malaria., Multi-gene families in malaria., Using parasite population genomics to improve understanding of malaria epidemiology, G4839860845, Studentship DTG Competition 2011, Improving the treatment of Plasmodium vivax, Developing drugs and vaccines for malaria by experimental studies in humans, Studies of hepatic latency in human ovale malaria, Optimising antimalarial combination therapies in an area coendemic for vivax and falciparum malaria, Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers, Pathophysiology and treatment of malaria and other tropical infectious diseases prevalent in our region
OpenAlex ID: W2581369360