Work

Pin1 : une peptidyl-prolylcis-transisomérase multifonctionnelle et une cible anticancéreuse prometteuse

Year: 2014

Type: review

Abstract: Post-translational modifications are critical to modulate protein function. A post-translational mechanism, peptidyl prolyl cis-trans isomerisation, plays a key role in protein regulation. Pin1 is a ubiquitous peptidyl prolyl cis-trans isomerase conserved from Archae to Human. This enzyme binds and isomerizes phospho-serine/threonine-proline motifs. This process can induce conformational change in protein targets and modulates their activity, cellular localization, phosphorylation state, stability and/or protein-protein interactions. Pin1 activity regulates proteins involved in cell proliferation, pluripotency or cellular invasion. Pin1 is overexpressed in several human cancers and contributes to tumorigenesis. Its inactivation constitutes a promising therapeutic strategy.

Source: médecine/sciences

DOI: 10.1051/medsci/20143008015

Authors: Justine Marsolier, Jonathan B. Weitzman

Institutions: Centre National de la Recherche Scientifique, Sorbonne Paris Cité, Epigénétique et Destin Cellulaire, Université Paris Diderot

Language: French

Topic: Signaling Pathways in Disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1966445467