Work

Thyroid Gland as a Target for Endocrine Chemical Disruptors

Year: 2015

Type: article

Abstract: Endocrine chemical disruptors (ECDs) are exogenous substances that may interfere with synthesis, secretion, transport, bind or metabolism of natural hormones in the organism. The aim of this review was to position the thyroid gland as a target of electrophiles toxicants. The thyroid demonstrated to be disrupted by polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), phthalates, perchlorate, organochlorines, dioxins, bisphenol A (BPA) flame-retardants, pesticides, polycyclic aromatic hydrocarbons (PAHs), and phytoestrogens. Regarding the chemical structure, many toxicants are electron deficient (electrophiles) that form covalent bonds with cognate electron rich (nucleophilic) sites on biological targets, promoting the toxic effects. Almost all ECDs recognized to interfere with thyroid hormone (THs) are electrophile and have hydrogen bond acceptor (HBA) sites in their chemical structure. Thyroid hormone production by the thyroid gland depends on H 2 O 2 generated by NADPH oxidases, and this reaction releases nucleophiles and electrophiles in the thyrocyte cytoplasm. Therefore, evidences suggest the interaction of electrophiles toxicants with nucleophiles from oxidative reactions in thyrocytes, which may compromise the thyroid gland function

Source: LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Authors: Patricia de Campos, Isabela Medeiros de Oliveira, Cláudio Alvarenga de Oliveira, Marco Aurélio Romano, Renata Marino Romano

Institution: Universidade Estadual do Centro-Oeste

Language: English

Topic: Effects and risks of endocrine disrupting chemicals

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2395314610

FWCI:

Cites: 27

Cited by: 1

Related to: 10