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Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells

Year: 2015
Type: article
Abstract: Nef-specific CD8(+) T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B*017:01-restricted Nef165-173IW9 epitope revealed highly restricted evolution. A common acute escape variant, T170I, unexpectedly and uniquely degraded Nef's major histocompatibility complex class I (MHC-I) downregulatory capacity, rendering the virus more vulnerable to CD8TL targeting other epitopes. These data aid in a mechanistic understanding of Nef functions and suggest means of immunity-mediated control of lentivirus replication.
DOI: 10.1128/jvi.01975-15
Authors: Andrea M. Weiler, Arpita Das, Oluwasayo Akinyosoye, Sherry Cui, Shelby L. O'Connor, Elizabeth A. Scheef, Jason S. Reed, Antonito T. Panganiban, Jonah B. Sacha, Eva G. Rakasz, Thomas C. Friedrich, Nicholas J. Maness
Language: English
Subfield: Virology
Open Access status: green
Awards: G3370103372, G4495922382, SIV antisense epitopes as novel markers of latency, G6680478677, G7160206448, G9000069411, Wisconsin National Primate Research Center Support, Nonhuman Primate Reagent Resource
OpenAlex ID: W2395849993
FWCI: 0.315
Cites: 44
Cited by: 4
Related to: 10