Work

Encapsulation of Gli-inhibitors blocks tumor invasion into the bone

Year: 2016

Type: conference-abstract

Abstract: Tumors including breast, prostate, lung, and oral cancer can establish in bone and disrupt normal bone remodeling.• Our group and others have shown that Gli2, a Hedgehog signaling transcription factor regulates parathyroid hormone related protein expression and bone destruction.• Genetic inhibition of Gli2 dramatically reduces tumor induced bone disease.• Hedgehog inhibitors have not been successful in most tumor in bone, since they often do not express Hedgehog receptors.• The available Gli inhibitors (including GANT58) are hydrophobic and challenging to deliver in vivo.

Source: Bone Abstracts

DOI: 10.1530/boneabs.5.p134

Authors: Joseph Vanderburgh, Shellese Cannonier, Kristin Kwakwa, Alyssa Merkel, Thomas Werfel, Craig Duvall, Scott Guelcher, Julie Sterling

Institutions: Vanderbilt University, VA Tennessee Valley Healthcare System, Vanderbilt University Medical Center

Language: English

Topic: Hedgehog Signaling Pathway Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2397199971

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