Non-immune IgG binding to the surface of spermatozoa by disulphide rearrangement.
Year: 1984
Type: article
Abstract: The mechanism whereby immunoglobulin binds to the surface of spermatozoa was investigated. IgG reacts with spermatozoa non-specifically via the Fc portion of the molecule, while both IgM and IgA are completely unreactive. This selective binding of IgG is non-competitive, resistant to heat, proteases and non-ionic detergents and is not mediated by an Fc receptor on the sperm surface. Instead, evidence is presented that IgG covalently binds to spermatozoa by an exchange reaction between labile disulphides on both the sperm surface and IgG-Fc. It is calculated that there are 3 X 10(11) exchangeable disulphide bonds per bull spermatozoon.
Source: PubMed Central
Authors: J M Richards, S S Witkin
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2397306001