Work

The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities

Year: 2016

Type: article

Abstract: Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2016.00049

Authors: Kathrin M. Bernt, Stephen P. Hunger, Tobias Neff

Institutions: Children's Hospital Colorado, University of Colorado Anschutz, University of Colorado Denver, Children's Hospital of Philadelphia

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801