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Preventive surgery is associated with reduced cancer risk and mortality in women with BRCA1 and BRCA2 mutations.

Year: 2011

Type: article

Abstract: Women who have inherited mutations in the BRCA1 or BRCA2 (BRCA1/2) genes have a substantially elevated risk of developing breast and ovarian cancer. For more than 10 years, researchers have studied whether preventive surgery (to remove breasts, ovaries, and/or fallopian tubes) can reduce the cancer and mortality risk in BRCA1/2 mutation carriers. This Issue Brief summarizes the results of the latest, largest, multinational study on the effects of preventive surgery in these women. The results are consistent with earlier studies and provide strong evidence for the use of preventive surgery as an effective approach to managing this genetic risk.

Source: PubMed

Authors: Susan M Domchek, Timothy R Rebbeck

Institutions: Leonard Davis Institute of Health Economics, University of Pennsylvania

Language: English

Topic: BRCA gene mutations in cancer

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Pennsylvania, National Cancer Institute

OpenAlex ID: W2397767998

FWCI: 0.55

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Cited by: 14

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