Year: 2002
Type: article
Abstract: Accommodation of the human stomach to a meal is a specialized motor function of the gastric corpus and fundus enabling high volume increase with minimal rise in intragastric pressure. This gastric function enables humans to ingest relatively large amount of solid or liquid meals without producing any postprandial symptoms such as vomiting. Gastric accommodation response is a predictable and robust reflex in health and it is mediated by vagal nonadrenergic, noncholinergic pathways that include a nitrergic synapse. A reduced gastric accommodation response can be seen in a variety of conditions such as functional dyspepsia, post-fundoplication dyspepsia, postvagotomy/gastric surgery, rumination syndrome and possibly, diabetes mellitus associated with vagal neuropathy. Measurement of gastric accommodation may facilitate our understanding of the cause of upper GI symptoms in the postprandial period in functional and neuropathic diseases, thereby impacting the outcomes of treatment.
Authors: Doe Young Kim, Michael Camilleri
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $500
OpenAlex ID: W2398038560