Work

Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery

Year: 2016

Type: review

Abstract: Brain delivery is one of the major challenges in drug development because of the high number of patients suffering from neural diseases and the low efficiency of the treatments available. Although the blood-brain barrier (BBB) prevents most drugs from reaching their targets, molecular vectors - known as BBB shuttles - offer great promise to safely overcome this formidable obstacle. In recent years, peptide shuttles have received growing attention because of their lower cost, reduced immunogenicity, and higher chemical versatility than traditional Trojan horse antibodies and other proteins.

Source: Chemical Society Reviews

DOI: 10.1039/c6cs00076b

Authors: Benjamí Oller-Salvia, Macarena Sánchez-Navarro, Ernest Giralt, Meritxell Teixidó

Institutions: Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Universitat de Barcelona

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Friedreich's Ataxia Research Alliance, Institute for Research in Biomedicine, Generalitat de Catalunya