A Case of Metachronous Multiple Endocrine Neoplasia Type I Manifested as Zollinger-Ellison Syndrome
Year: 2002
Type: article
Study design: Case Report
Abstract: Zollinger-Ellison syndrome (ZES) is characterized by recurrent peptic ulcer and diarrhea caused by gastric acid hypersecretion due to gastrinoma. Approximately, one third of patients with gastrinoma have multiple endocrine neoplasia type I (MEN-I). The diagnosis of gastrinoma is difficult, although it can be cured by surgery after localization. Recently, the somatostatin receptor scintigraphy (SRS) was reported to be more sensitive than any other tumor-localization methods. We report a case of ZES with metachronous MEN-I. A 47-year-old woman had peptic ulcer disease with its complications and recently developed diarrhea. Her serum gastrin level was markedly elevated (1,098pg/mL) but the results of conventional imaging tests were negative. We confirmed the presence of gastrinoma by the selective intraarterial secretin injection and portal vein sampling. Then, the tumor was eventually located by SRS under the diagnosis of ZES. She underwent a Whipple`s operation with the compatible pathologic findings of gastrinoma. She was confirmed to have parathyroid hyperplasia and MEN-I during follow-up. (Korean J Gastroenterol 2002;39:50-54)
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $7
OpenAlex ID: W2261986257