Paradoxical role of SOX2 in gastric cancer.
Year: 2016
Type: review
Abstract: Sox2 is a critical regulator of embryogenesis and necessary for cellular reprogramming. It also plays an important role in tissue homeostasis and regeneration, maintaining the population of undifferentiated adult stem cells. Like various developmental and stem cell genes, SOX2 is aberrantly expressed and amplified in several human cancers. Moreover, functional studies have shown that it regulates many biological processes including cell proliferation, apoptosis, self-renewal and invasion. While it is oncogenic in most cancers, SOX2 activity is controversial in gastric cancer, where it might behave as a tumor suppressor in some situations. In this review, we discuss its role in cancer biology, with particular attention to what is known about the involvement of SOX2 in gastric cancer biology.
Source: PubMed
Authors: Estefania Carrasco-Garcia, Juliana C Santos, Idoia Garcia, Mitsue Brianti, Mikel García-Puga, José Pedrazzoli, Ander Matheu, Marcelo L Ribeiro
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2399293392