Work

Is there a role for microRNAs in exercise immunology? - A synopsis of current literature and future developments

Year: 2026

Type: article

Abstract: With the discovery of microRNAs (miRNAs), an exceptional means of regulating gene expression was introduced a few years ago. MiRNAs function to inactivate specific messenger RNA transcripts leading to depletion of the corresponding protein, whereby computational studies have shown that about one third of all animal genes might be miRNA targets. Recent publications highlight the involvement of miRNAs in regulating the immune response. The aim of this review is to provide an overview of miRNA biogenesis and function, to illustrate their impact on both the innate as well as the adaptive immune system, to show the regulation of skeletal muscle plasticity and inflammation, and finally to present their possible role within the field of exercise immunology.

Source: PubMed

DOI: 10.22029/eir.2010.1649

Authors: Wessner, Barbara, Gryadunov-Masutti, Laura, Tschan, Harald, Bachl, Norbert, Roth, Erich

Institutions: University of Vienna, Medical University of Vienna

Language: English

Topic: Exercise and Physiological Responses

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2400668158

FWCI: 3.484

Cites: 81

Cited by: 17

Related to: 10