Serum Adiponectin as a Predictor for Cardiovascular Outcomes in Non-Diabetic End-Stage Renal Disease Patients
Year: 2010
Type: article
Study design: Observational Study
Abstract: Purpose: Adiponectin (ADPN) has been known to protect against cardiovascular disease (CVD) in\nmetabolic syndrome with normal renal function for its anti-inflammatory and anti-atherogenic property.\nHowever, it is still unclear whether ADPN is associated with cardiovascular outcomes in end-stage\nrenal disease (ESRD) patients.\nMethods: This study included 80 non-diabetic ESRD patients [mean age, 52.8짹13.7 years; dialysis\nduration, 67.1짹52.0 months; hemodialysis (HD), 35 pts; peritoneal dialysis (PD), 45 pts] who survived\nfor more than 3 months after the start of dialysis, and serum ADPN levels were measured at the beginning\nof the study. We conducted a longitudinal follow-up to evaluate the association of serum ADPN\nlevel with cardiovascular outcomes for 29.3짹6.7 months.\nResults: ADPN was inversely correlated with fasting serum insulin (r=-0.309, p=0.006) and HOMA-IR\n(r=-0.321, p=0.004) in ESRD patients. In a multiple linear regression analysis adjusted for age, gender,\nwaist to hip ratio (WHR), and HDL-cholesterol, HOMA-IR (棺=-0.880, p=0.041) was an independent\nfactor associated with serum ADPN level. Kaplan-Meier analysis revealed that patients with higher\nADPN levels (�돟15.8 關g/mL) had a significantly higher survival rate compared with lowers (<15.8 關g/\nmL) (p=0.032). Cox proportional hazard model adjusted for age, WHR, creatinine, CRP, and previous\nCVD history revealed that serum ADPN level (HR, 0.899; 95% CI, 0.818-0.987; p=0.026) was an independent\ndeterminant of cardiovascular outcomes.\nConclusion: These findings suggest that lower ADPN levels independently predict cardiovascular events\nin non-diabetic ESRD patients.
Authors: Hye Rim An, Sung Jin Moon, Hyeong Cheon Park, Yong Kyu Lee, Jwa-Kyung Kim, Beom Seok Kim, Hyung‐Jong Kim, Dae Suk Han, Sung Kyu Ha
Institution: Severance Hospital
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2401831758