Work

Apposition of mononuclear cells to langerhans cells in contact allergic reactions. An ultrastructural study

Year: 1973

Type: article

Abstract: The 111lrastruc1urnl fcaturcs of Langerhans cell, are describcd in positive coniact allergic anti contacl irri1an1 reactions and 111 clinically negative patch test sitcs.Skin biopsies of po,itive patch test reactions to ninc differcn1 allergen, in 21 allcrgic subjccts werc examined by electron microscopy.As conlrols, skin biopsies wcrc studied I) of clinically non-reactive patch tc�I sites to fivc different allergens in 23 subjec1,.2) of contact irrirnnt reac1ions in 5 ,ubjects, and 3) of lcsions of 9 subjects with variou� dcrmaloscs.Closc apposition of mononuclcar cells 10 l.angerhan� cells wa, ,;een almo,t exclusi, ely at si tes of contact allcrgic reac tions.Somc of these Langerhan, cells ,howed prominent Oolgi complcxes, channcls of rough endoplasmic retic ulum, polyribosomes, ly�o,ome-likc bodies, and ruffled cell membrnne, with p�eudopod-likc projections.Still other Langcrhans cells showed di�ruption of their cell membranes.The resuh, of this s111dy suggcst that the Langerhans cell, for which no function is known, plays a role in contnct alJergic reactions.l he nature of thi, role requires further s11,dy.

Source: Acta Dermato Venereologica

DOI: 10.2340/0001555553112

Author: I. Silberberg

Institution: New York University

Language: English

Topic: Contact Dermatitis and Allergies

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,725