Work

[3 + 2]-Cycloadditions of Azomethine Imines and Ynolates

Year: 2016

Type: article

Abstract: A novel [3 + 2]-cycloaddition between azomethine imines and lithium ynolates is described to synthesize bicyclic pyrazolidinones. These bicyclic pyrazolidinones are versatile intermediates to form β-amino acids and monocyclic pyrazolidinones. High diastereoselectivity and stereospecificity allow access to optically active products.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6b01104

Authors: Sarah E. Winterton, Joseph M. Ready

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Welch Foundation, National Institute of General Medical Sciences

Awards: G3600524734, G7073091334, Synthesis and Evaluation of Biologically Active Natural Products