Pre-existing diabetes and lung cancer prognosis

Year: 2016

Type: article

Abstract: BACKGROUND: The aims of this study are to investigate the impact of pre-existing diabetes and diabetes treatments on lung cancer prognosis. METHODS: A total of 2484 women with confirmed incident lung cancer from the Women's Health Initiative were followed for an average of 2.9 years through the date of death or 29 August 2014. RESULTS: Compared with women with lung cancer but without diabetes, women with lung cancer and diabetes had significantly increased risk of overall mortality (HR=1.27, 95% CI: 1.07-1.50). Women with diabetes receiving insulin or metformin or women who had long duration of diabetes also had increased risk of overall mortality. CONCLUSIONS: Our large prospective study provides evidence that pre-existing diabetes is associated with poor overall survival among women with lung cancer, but do not support the hypothesis that metformin use may have a protective effect in women with lung cancer and diabetes.

Source: British Journal of Cancer

DOI: 10.1038/bjc.2016.141

Authors: Juhua Luo, Michael Hendryx, Lihong Qi, Gloria YF Ho, Karen L Margolis

Institutions: Indiana University Bloomington, Indiana University, University of California, Davis, Northwell Health, Feinstein Institute for Medical Research, HealthPartners

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute, National Center for Advancing Translational Sciences

OpenAlex ID: W2402386880