Work

The phenomenon of multi-drug resistance in the treatment of malignant tumors.

Year: 2014

Type: article

Abstract: Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in tre-ating breast cancer. Physiological functions and contribution to MDR development of ABC-transporter protein families have been described. The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown.

Source: PubMed

Authors: S V Vtorushin, K Y Khristenko, M V Zavyalova, V M Perelmuter, N V Litviakov, E V Denisov, A Y Dulesova, N V Cherdyntseva

Institutions: Siberian State Medical University, Tomsk Cancer Research Institute, National Research Tomsk State University

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Russian Foundation for Basic Research

OpenAlex ID: W2402596883

FWCI: 2.827

Cites: 180

Cited by: 41

Related to: 10