Insulin and adrenalin effects on the activity and concentration of glutathione metabolizing enzymes in rat organs
Year: 1994
Type: article
Abstract: Adrenaline activates glutathione peroxidase in the heart, liver, and kidneys and glutathione transferase in the heart and liver, inhibits gamma-glutamyl transferase in the kidneys, and has no effect on glutathione reductase; no changes in the brain detected. Insulin does not influence glutathione reductase either, nor does it induce any changes in the heart, liver, and bone marrow, but it alters (as a rule reduces) in a number of cases the activities of many glutathione metabolism enzymes and reduces glutathione concentration in the brain, kidneys, and spleen both an hour and 24 h after injection. The detected changes do not conform to universally acknowledged classification of the organs by insulin sensitivity and do not correlate with hypoglycemia.
Source: Problems of Endocrinology
DOI: 10.14341/probl12015
Authors: L. S. Kolesnichenko, V. I. Kulinsky, M. V. Yasko, G. A. Pensionerova, Yu. V. Grudinina
Institution: Irkutsk State Medical University
Language: Russian
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2979526793