Work

Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica

Year: 2016

Type: article

Abstract: We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any peptide or protein from spiders of the Scytodidae family. Many venom peptides target neuronal ion channels or receptors. However, we have not been able to determine the target of these Scytodes peptides so we can only state with certainty the channels and receptors that they do not target.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0156291

Authors: Nathanial K. Ariki, Lisa E. Muñoz, Elizabeth L. Armitage, Francesca R. Goodstein, Kathryn G. George, Vanessa L. Smith, Irina Vetter, Volker Herzig, Glenn F. King, Nikolaus M. Loening

Institutions: Lewis & Clark College, The University of Queensland, Institute for Molecular Bioscience

Language: English

Topic: Venomous Animal Envenomation and Studies

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,382

Funders: Department of Agriculture, Fisheries and Forestry, Australian Government, University of North Carolina at Chapel Hill, Medical Research Council, Australian Research Council, National Institute of Mental Health, National Institute of General Medical Sciences

Awards: G1915163810, G2521831283, A novel approach for controlling insect vectors of human disease, Structural Studies and Char. of Neurotoxic Venom Peptides from Sicariidae Spiders

OpenAlex ID: W2403055362

FWCI: 1.076

Cites: 52

Cited by: 9

Related to: 10