Síndrome de Turner: Crecimiento y descripción clínica en 83 niñas chilenas
Year: 2002
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Short stature is the main feature of patients with Turner's syndrome. There is limited information regarding the spontaneous growth of these patients in Chile. AIM: To develop a specific growth chart for Chilean patients with Turner's syndrome. MATERIAL AND METHODS: We retrospectively analyzed 668 height measurements from 85 Chilean girls, born after 1968, with 45XO karyotype (minimum 15%), and without an Y chromosome fragment. Patients with hormonal therapy, such as growth hormone or estrogen, except thyroid hormone replacement, were excluded. RESULTS: The karyotypes were 60% 45XO, 25% 45XO, 46XX, and 15% other complex mosaics. The birth length was 46.8 +/- 2.1 cm. The final height of our patients was 138,20 +/- 7.0 cm. CONCLUSIONS: The final height achieved by our patients, is similar to Argentinian and Japanese patients, but is below the mean stature reported for Scandinavian and Northamerican patients who achieve a mean adult height of approximately 147 and 142 cm respectively. The birth length is also lower than that reported in those studies.
Source: Revista médica de Chile
Authors: Rossana Román, María Eliana Vallejos, Mónica Muñoz, Ruth Schneider, Ronald Youlton, Cecilia Henriquez, Fernando Cassorla
Language: Spanish
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1974081385