Effect of pinealectomy on immune reactions in the rat.
Year: 1970
Type: article
Abstract: Non-inbred Wistar rats were pinealectomized at birth or in adult life, and tested for classical immune responses. Neonatal pinealectomy did not exert any notable effect on immune capacity of rats. On the other hand, rats pinealectomized at 6 weeks of age showed partial and transient impairment of immune potential. Arthus reactivity to bovine serum albumin was diminished and oedema of the skin less pronounced, and delayed reactions were reduced and of short duration. Slight delay in homograft rejection was noted. The incidence of allergic encephalomyelitis was diminished, and no clinical signs were observed. The cellular make-up of lymphoid tissues of pinealectomized adult rats was normal.
Source: PubMed Central
Authors: B D Janković, K Isaković, S Petrović
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2404453684