Work

The potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases

Year: 2016

Type: review

Abstract: Hydrogen, one of the most well-known natural molecules, has been used in numerous medical applications owing to its ability to selectively neutralize cytotoxic reactive oxygen species and ameliorate hazardous inflammations. Hydrogen can exert protective effects on various reactive oxygen species-related diseases, including the transplantation-induced intestinal graft injury, chronic inflammation, ischemia-reperfusion injuries, and so on. Especially in the eye, hydrogen has been used to counteract multiple ocular pathologies in the ophthalmological models. Herein, the ophthalmological utilizations of hydrogen are systematically reviewed and the underlying mechanisms of hydrogen-induced beneficial effects are discussed. It is our hope that the protective effects of hydrogen, as evidenced by these pioneering studies, would enrich our pharmacological knowledge about this natural element and cast light into the discovery of a novel therapeutic strategy against ocular diseases.

Source: Therapeutics and Clinical Risk Management

DOI: 10.2147/tcrm.s102518

Authors: Yi Fei Huang, Ye Tao, Lei Geng, weiwei Xu, Guanghua Peng, Limin Qin

Institutions: Chinese PLA General Hospital, Chinese People's Liberation Army

Language: English

Topic: Hydrogen's biological and therapeutic effects

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836