Suppression of delayed-type hypersensitivity to histocompatibility antigens by ultraviolet radiation.
Year: 1987
Type: article
Abstract: Delayed-type hypersensitivity (DTH) reactions to allogeneic histocompatibility antigens in mice could be systemically suppressed by a single exposure to UV-B irradiation. The extent of suppression reached its maximum 4 days after irradiation, gradually waned thereafter, and disappeared at Day 21. Re-exposure of these mice to UV-B after waning reinduced the state of suppression. The suppression could be transferred to naive mice by means of splenic T lymphocytes. The suppressor T (Ts) cells suppressed the proliferative activity in the lymph nodes draining the site of immunization, but not the activity of already activated DTH-reactive T cells. Phenotypical analysis of these Ts cells revealed that two subpopulations of T cells are involved: one with the Lyt-1+, 2- phenotype, the other with the Lyt-1-, 2+ phenotype.
Source: PubMed Central
Authors: A Molendijk, R J van Gurp, I G Donselaar, R Benner
Institution: Erasmus University Rotterdam
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2404785810